Biochemistry

BIOCHEMISTRY          In the scientific diary article deoxyribonucleic acid Aptamers Selected against the HIV-1 ribonucleinase H Display in Antiviral Activity from the Biochemistry diary the researchers were talking abtaboo an restrictor of the ribonuclease H activity on RNA-DNA hybrids. Since they know that a vaccination against HIV-1 is still a coarse goal. They want to make an debaror that will be more emotional at blocking the viral replication and thus slowly the onset and progression of the HIV-1 virus. The article states that new masterors have been build using the SELEX method that means systematic evolution of ligands by exponential enrichment. In the article the scientists employ SELEX to discriminate ligands that inhibit ribonuclease H activity associated with the HIV-1 RT. With SELEX scientists have been able to seclude oligonucleotide sequences, which atomic number 18 emerging as a class of molecules that play off antibodies. Many of the oligonucleotides selectively inhibit the DNA polymerase actively. Most of the compounds inhibiting the HIV-1 mold by inhibiting the DNA polymerase give-up the ghost on the RT. Some of these compounds are AZT, ddI, ddC, and nevirapine.

        In the try that they carried out they found that the molecules that they chose in this experiment do not destiny features with the DNA aptamers previously detached against the HIV-1 RT. The aptamers were predicted to form pseudoknots, but they did not. The selected DNA ligands shared little or no structural parity with RNA aptamers. But this is judge since the RNA chains of the aforemen! tioned(prenominal) sequence do not usually adopt the geometry select by the DNA. In destruction the results of the scientists that carried out the experiment showed that the oligonucleotides used were powerful inhibitors of the HIV-1 virus. If you want to hit a full essay, localise it on our website: BestEssayCheap.com

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